Publication

Journal Articles

2023

  • Toscano-Márquez, B., Leung, T. C. S., Hui, J., Charron, F., McKinney, R.A., and A.J. Watt (2023). A mitochondrial-targeted antioxidant (MitoQ) improves motor coordination and reverses Purkinje cell death in a mouse model of ARSACSl. Neurobiology of Disease 183: 106157 doi.org/10.1016/j.nbd.2023.106157

2022

  • Cook, A. A., Jayabal, S., Sheng, J., Fields, E, Leung, S., Quilez, S., Mcnicholas, E., Lau, L., Huang, S., andA.J. Watt (2022) Activation of TrkB-Akt signaling rescues deficits in a mouse model of SCA6. Science Advances 8 (37). doi: 10.1126/sciadv.abh3260
    • Press release for this article can be found here
  • Chang HHV, Cook AA, Watt AJ, Cullen KE. (2022) Loss of Flocculus Purkinje Cell Firing Precision Leads to Impaired Gaze Stabilization in a Mouse Model of Spinocerebellar Ataxia Type 6 (SCA6). Cells 11(17):2739. https://doi.org/10.3390/cells11172739

2021

  • Toscano-Márquez, B., Cook, A.A., Rice, M., Smileski, A., Vieira-Lomasaney, K., Charron, F., McKinney, R.A., and A.J. Watt (2021) Molecular identity and location influence Purkinje cell vulnerability in ARSACS mice. Frontiers in Cellular Neuroscience https://www.frontiersin.org/articles/10.3389/fncel.2021.707857/
    • Press release for this article can be found here.
    • This work has been featured on CBC Radio Let’s Go here.
  • Lang-Ouellette, D., Gruver, K.M., Smith-Dijak, A., Blot, F.G.C., Stewart, C., de Vanssay de Blavous, P., Li, C., van Eitrem, C., Rosen, C., Faust, P.L., Schonewille, M., and A.J. Watt (2021) Purkinje cell axonal swellings enhance axonal spike fidelity and cerebellar function. Nature Communications 12 (4129) https://doi.org/10.1038/s41467-021-24390-4
    • Press release for this article can be found here.
  • Hooshmandi, M. Truong, V.T., Fields, E., Thomas, R.E., Wong, C., Sharma, V., Gantois, I., Roque, P.S. Chalkiadaki, K., Wu, N., Chakraborty, A., Tahmasebi, S., Prager-Khoutorsky, M., Sonenberg, N., Suvrathan, A., Watt, A.J., Gkogkas, C.G., and Khoutorsky, A (2021). 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. Cell Reports. doi.org/10.1016/j.celrep.2021.109036

2020

2019

  • Gruver, K. M., and A.J. Watt (2019). Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje cell – DCN synapse. Frontiers in Synaptic Neuroscience. 11 (31) doi.org/10.3389/fnsyn.2019.00031
  • Leung, S., McKinney, R.A. and A.J. Watt (2019) Brain development: the impact of light during the night. eLife 2019;8:e52364 doi: 10.7554/eLife.52364
  • Li, L., Jayabal, S., Ghorbani, M., Legault, L.-M., McGraw, S., Watt, A.J., and X.-J. Yang. (2019). ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation. Cellular and Molecular Life Sciences  https://doi.org/10.1007/s00018-019-03088-3
  • Larivière, R., Sgarioto, N., Toscano-Márquez, B., Gaudet, R., Choquet, K., McKinney, R.A., Watt, A.J., and B. Brais (2019). Sacs R272C missense homozygous mice develop an ataxia phenotype. Molecular Brain 12: 19. https://doi.org/10.1186/s13041-019-0438-3

2018

  • Ady, V., Toscano-Márquez, B., Nath, M.,Chang, P. K.Y., Hui, J., Cook, A., Charron, F., Larivière, R., Brais, B., McKinney, R.A., and A.J. Watt (2018) Altered synaptic and firing properties of cerebellar Purkinje cells in a mouse model of ARSACS. Journal of Physiology. 596(17): 4253-4267. https://doi.org/10.1113/JP275902

2017

  • Jayabal, S., Ljungberg, L., and A.J. Watt (2017) Transient cerebellar alterations during development prior to disease onset in a mouse model of spinocerebellar ataxia type 6. Journal of Physiology 595(3): 949-966. https://doi.org/10.1113/JP273184

2016

  • Ljungberg, L., Lang-Ouellette, D., Yang, A., Quilez, S., Jayabal, S., and A.J. Watt (2016). Transient developmental Purkinje cell axonal torpedoes in healthy and ataxic mouse cerebellum. Frontiers in Cellular Neuroscience 10: 248. https://doi.org/10.3389/fncel.2016.00248
  • Jayabal, S., Chang, H.H.V., Cullen, K.E., and A.J. Watt (2016) 4-Aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6. Scientific Reports 6: 29489 https://doi.org/10.1038/srep29489
  • Abrahamsson, T., Lalanne, T, Watt, A.J., and P.J. Sjöström (2016) Long-term potentiation by theta-burst stimulation using extracellular field potential recordings in acute hippocampal slices. Cold Spring Harbor Protocols doi:10.1101/pdb.prot091298
  • Abrahamsson, T., Lalanne, T, Watt, A.J., and P.J. Sjöström (2016) In vitro investigation of synaptic plasticity. Cold Spring Harbor Protocols doi:10.1101/pdb.top087262

2015

  • Jayabal, S., Ljungberg, L., Erwes, T., Cormier, A., Quilez, S., El Jaouhari, S., and A.J. Watt (2015) Rapid onset of motor deficits in a mouse model of spinocerebellar ataxia type 6 precedes late cerebellar degeneration. eNeuro 2(6): e00094-15.2015 1-18

2014

  • Ferreira, T.A., Blackman, A.V., Oyrer, J., Chung, A.J., Jayabal, S.*, Watt, A.J., Sjostrom, P.J., and D.J. van Meyel. (2014) Neuronal morphometry directly from bitmap images. Nature Methods, 11: 982-984 https://doi.org/10.1038/nmeth.3125

2013

  • Costa, R. P., Watt, A.J., and P.J. Sjöström. (2013) How to train a neuron. eLife 10.7554/eLife.00491

2011

2010

  • Watt, A.J., and N.S. Desai. (2010) Homeostatic plasticity and STDP: keeping a neuron’s cool in a fluctuating world. Frontiers in Synaptic Neuroscience 2:5 https://doi.org/10.3389/fnsyn.2010.00005

2009

  • Watt, A.J., Cuntz, H., Mori, M., Nusser, Z., Sjöström, P.J and Häusser, M. (2009). Traveling waves in developing cerebellar cortex mediated by asymmetrically connected Purkinje cells. Nature Neuroscience, 12: 463-473 https://doi.org/10.1038/nn.2285

2004

  • Watt, A.J., Sjöström, P.J., Häusser, M., Nelson, S.B., and Turrigiano, G.G. (2004). A proportional but slower NMDA potentiation follows AMPA potentiation in LTP. Nature Neuroscience, 7: 518-524 https://doi.org/10.1038/nn1220

2003

  • Pratt, K.G., Watt, A.J., Griffith, L.C., Nelson, S.B., and Turrigiano, G.G. (2003). Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII. Neuron, 39: 269-281 DOI:https://doi.org/10.1016/S0896-6273(03)00422-7

2000

1999

  • Billon, N., Carlisi, D., Datto, M.B., van Grunsven, L.A., Watt, A.J., Wang, X.-F., and Rudkin, B.B. (1999). Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Oncogene, 18: 2872-2882 https://doi.org/10.1038/sj.onc.1202712

Book Chapters

  • Toscano-Márquez, B., Cook, A.A., Rice, M., Smileski, A., Vieira-Lomasaney, K., Charron, F., McKinney, R.A., and A.J. Watt (2022) “Molecular identity and location influence Purkinje cell vulnerability in ARSACS mice.” in Biology of Brain Disorders — Cellular substrates for disrupted synaptic function and experience-dependent plasticity. Frontiers Media SA. Edited by Tropea, D., Banerjee, A, and A. Scimemi. p. 298-330. 
  • Gruver, K. M., and A.J. Watt (2020). “Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje cell – DCN synapse” in Methods for Synaptic Interrogation. Frontiers Media SA. Edited by Feldmeyer, D., Wesseling, J.F., and P.J. Sjöström. p. 201-208.  
  • Jayabal, S., and A.J. Watt (2019).“Turning on the juice: the development of physiological activity in the cerebellum” in  Handbook of the Cerebellum and Cerebellar Disorders, 2nd edition. Springer Publishing.Edited by Manto, M., Gruol, D.L., Schmahmann, J.D., Koibushi, N., and Sillitoe, R.V.
  • Abrahamsson, T., Lalanne, T, Watt, A.J., and P.J. Sjöström. (2017). “In Vitro investigation of Synaptic Plasticity” in Ion Channels. Cold Spring Harbor Press. Edited by Kammermeier, P., Duguid, I., and S. Brenowitz. 
  • Watt, A.J., and N.S. Desai. “Homeostatic plasticity and STDP: keeping a neuron’s cool in a fluctuating world” in Spike-Timing-Dependent Plasticity: A Comprehensive Overview. Frontiers Media SA, 2012, p. 240 -255